Calculate the sum of the numbers in corresponding positions of the outer 4 squares, subtract 5 form this result, and put it in the corresponding position of the middle square, 1/4 turn anticlockwise from the original.
Working from top to bottom, reading each pair of numbers as a 2 digit value, values represent the reverse alphabetical value of letters of the alphabet, starting with A, written with 3 straight lines only.
Starting with the circle on the top left, and moving to the right, top row then bottom row, the sum of the numbers in each circle follows the sequence 12, 15, 18, 21 etc.
Split the whole diagram in half, horizontally, to give two groups of 5 octagons. In each group, the central number in the top row equals the sum of the surrounding 4 numbers.
Reading each row as a 3 or 2 digit number, subtract the central 2 digit value from the upper 3 digit value, to give the 3 digit result on the lower row.
Starting with the left hand circle, add 4 to each number and rotate their positions 1 place clockwise to give the values in the upper right hand circle, then add 5 to each of these values and rotate their positions 1 place clockwise to give the values in the lower right hand circle.