In each row, the middle value equals the sum of the left and right hand values, adding 2 for the top row, 4 for the middle row, and 6 for the bottom row.
Numbers in the segments of the upper left hand circle equal the product of the numbers in corresponding segments of the lower 2 circles, and the numbers in the segments of the upper right hand circle equal the sum of the numbers in corresponding segments of the bottom two circles.